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Dexpramipexole dihydrochloride

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Purity:99.44%

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COA HPLC HNMR

Dexpramipexole dihydrochloride

Catalog No. T11011Cas No. 104632-27-1

Dexpramipexole dihydrochloride (KNS-760704 dihydrochloride) ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and is a weak non-ergoline dopamine agonist.

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Pack Size	Price	Availability
5 mg	$44	In Stock
10 mg	$72	In Stock
25 mg	$155	In Stock
50 mg	$263	In Stock
100 mg	$397	In Stock
200 mg	$582	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Product Introduction

Bioactivity

Description	Dexpramipexole dihydrochloride (KNS-760704 dihydrochloride) ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and is a weak non-ergoline dopamine agonist.
In vitro	Dextromethorphan has been found to have neuroprotective effects and is being studied for the treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptosis pathways, and improves cell survival in response to various neurotoxins and β-amyloid neurotoxicity. Compared with the S-(-) isomer, dextromethorphan has lower dopamine agonist activity.
Alias	KNS-760704 dihydrochloride, R-(+)-Pramipexole dihydrochloride, (R)-Pramipexole dihydrochloride

Chemical Properties

Molecular Weight	284.25
Formula	C10H19Cl2N3S
Cas No.	104632-27-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (351.80 mM)

H2O: 100 mg/mL (351.80 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5180 mL	17.5901 mL	35.1803 mL	175.9015 mL
5 mM	0.7036 mL	3.5180 mL	7.0361 mL	35.1803 mL
10 mM	0.3518 mL	1.7590 mL	3.5180 mL	17.5901 mL
20 mM	0.1759 mL	0.8795 mL	1.7590 mL	8.7951 mL
50 mM	0.0704 mL	0.3518 mL	0.7036 mL	3.5180 mL
100 mM	0.0352 mL	0.1759 mL	0.3518 mL	1.7590 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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